2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-109083A
    Cilofexor tromethamine 2253764-93-9 98%
    Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal farnesene oxide receptor agonist with activity in improving markers of cholestasis and liver injury. Cilofexor tromethamine was shown to be well tolerated in patients without cirrhosis and resulted in significant improvements in liver biochemical parameters and cholestatic markers. Cilofexor tromethamine offers a potential inhibitory option for the management of primary sclerosing cholangitis.
    Cilofexor tromethamine
  • HY-109092A
    rel-Licogliflozin 2730989-98-5 98%
    rel-Licogliflozin is a relative configuration of Licogliflozin (HY-109092). Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.
    rel-Licogliflozin
  • HY-109114A
    Dersimelagon phosphate 2490660-87-0 98%
    Dersimelagon phosphate is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon phosphate shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon phosphate can be used for the research of skin pigmentation.
    Dersimelagon phosphate
  • HY-109120S
    Odevixibat-d5 98%
    Odevixibat-d5 is deuterated labeled Odevixibat (HY-109120). Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis.
    Odevixibat-d5
  • HY-109134A
    Pizuglanstat hydrate 1584160-52-0 98%
    Pizuglanstat hydrate (Compound 3; TAS-205) is an orally active prostaglandin D synthase inhibitor with an IC50 of 76 nM for human hematopoietic prostaglandin D synthase. Pizuglanstat hydrate inhibits the synthesis of PGD2. Pizuglanstat hydrate improves experimental allergic rhinitis. Pizuglanstat hydrate can be used in the study of muscle regenerative diseases such as muscular dystrophy.
    Pizuglanstat hydrate
  • HY-109591C
    9(Z)-Octadecenoyl coenzyme A potassium 369657-01-2 98%
    9(Z)-Octadecenoyl coenzyme A (potassium) is an ester product.
    9(Z)-Octadecenoyl coenzyme A potassium
  • HY-109654R
    Ensulizole (Standard) 27503-81-7
    Ensulizole (Standard) is the analytical standard of Ensulizole. This product is intended for research and analytical applications. Ensulizole is a sulfonated UV absorber and can intense UVB and partial UVA absorption. Ensulizole can damage the DNA through the generation of reactive oxygen species (ROS) upon UV or sunlight irradiation.
    Ensulizole (Standard)
  • HY-110034R
    Didesmethylsibutramine hydrochloride (Standard) 84484-78-6
    Didesmethylsibutramine (hydrochloride) (Standard) is the analytical standard of Didesmethylsibutramine (hydrochloride). This product is intended for research and analytical applications. Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis.
    Didesmethylsibutramine hydrochloride (Standard)
  • HY-111174R
    Diprotin A (Standard) 90614-48-5
    Diprotin A (Standard) is the analytical standard of Diprotin A. This product is intended for research and analytical applications. Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].
    Diprotin A (Standard)
  • HY-111431R
    p-Cresyl sulfate (Standard) 3233-58-7
    Platycodin D (Standard) is the analytical standard of Platycodin D. This product is intended for research and analytical applications. Platycodin D is a saponin isolated from Platycodon grandiflorus, acts as an activator of AMPKα, with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D.
    p-Cresyl sulfate (Standard)
  • HY-111614R
    Melengestrol acetate (Standard) 2919-66-6
    Melengestrol acetate (Standard) is the analytical standard of Melengestrol acetate. This product is intended for research and analytical applications. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate (Standard)
  • HY-111614S
    Melengestrol acetate-d6 98%
    Melengestrol acetate-d6 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate-d6
  • HY-112102R
    (22S,23S)-Homobrassinolide (Standard) 80483-89-2
    (22S,23S)-Homobrassinolide (Standard) is the analytical standard of (22S,23S)-Homobrassinolide. This product is intended for research and analytical applications. (22S,23S)-Homobrassinolide is one of the most active brassinosteroids in inducing plant growth in various plant bioassay systems. (22S,23S)-Homobrassinolide shows Akt-dependent anabolic activity in rat skeletal muscle cells. Orally active[1].
    (22S,23S)-Homobrassinolide (Standard)
  • HY-112530S
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 326495-43-6 ≥99.0%
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine. 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a phosphoethanolamine (PE) lipid that can be used in the synthesis
    1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine-d70
  • HY-112537A
    Dipotassium glucose-6-phosphate, 98% 5996-17-8 98%
    D-Glucose-6-phosphate dipotassium salt dihydrate is a glucose sugar phosphorylated at the hydroxy group on carbon 6.
    Dipotassium glucose-6-phosphate, 98%
  • HY-112573A
    Azapentacene sodium 3863-80-7 98%
    Azapentacene sodium is an anti-cataract agent.
    Azapentacene sodium
  • HY-112603A
    AP5 sodium 1623143-67-8 98%
    AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC50 values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research.
    AP5 sodium
  • HY-112755A
    1,2(R)-Dioleyloxy-3-dimethylamino-propane 666234-78-2 98%
    1,2(R)-Dioleyloxy-3-dimethylamino-propane ((R)-DODMA) is an ionizable cationic lipid and an isomer of DODMA (HY-112755).
    1,2(R)-Dioleyloxy-3-dimethylamino-propane
  • HY-113013A
    Hydroxypyruvic acid lithium hydrate 209728-15-4 98%
    Hydroxypyruvic acid lithium hydrate (β-Hydroxypyruvic acid lithium hydrate) is an intermediate in the metabolism of glycine, serine and threonine. Hydroxypyruvic acid lithium hydrate is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. Hydroxypyruvic acid lithium hydrate is involved in the metabolic disorder which is the dimethylglycine dehydrogenase deficiency pathway.
    Hydroxypyruvic acid lithium hydrate
  • HY-113016R
    Elaidic acid (Standard) 112-79-8
    Elaidic acid (Standard) is the analytical standard of Elaidic acid. This product is intended for research and analytical applications. Elaidic acid is the major trans fat found in hydrogenated vegetable oils and can be used as a pharmaceutical solvent.
    Elaidic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity